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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $143 | In Stock | |
5 mg | $297 | In Stock | |
10 mg | $455 | In Stock | |
25 mg | $745 | In Stock | |
50 mg | $987 | In Stock | |
100 mg | $1,360 | In Stock | |
1 mL x 10 mM (in DMSO) | $336 | In Stock |
Description | nAChR agonist 1 (DUN71755) is a brain-permeable and orally efficacious positive allosteric α7 nicotinic acetylcholine receptor (α7 nAChR)modulator. |
In vivo | nAChR agonist 1(compound 28) is a novel PAM of α7 nicotinic acetylcholine receptor (α7 nAChR).?Compound 28 showed good in vitro potency, with pharmacokinetic profile across species with excellent brain penetration and residence time.?Compound 28 robustly reversed the cognitive deficits in episodic/working memory in both time-delay and scopolamine-induced amnesia paradigms in the novel object and social recognition tasks, at very low dose levels. |
Alias | DUN71755 |
Molecular Weight | 419.94 |
Formula | C20H18ClNO3S2 |
Cas No. | 1394371-75-5 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 120 mg/mL (285.76 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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